Metabotropic Glutamate Receptor 5 anticorps (N-Term)

N° du produit ABIN2469508

Détail du produit anti-Metabotropic Glutamate Receptor 5 anticorps

Antigène: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Épitope: N-Term

Reactivité: Rat, Humain, Souris, Poulet, Chien, Singe, Porc, Cheval, Roussette (Chauve-souris), Boeuf (Vache), Lapin, Hamster, Gibbon

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 5 est non-conjugé

Application: Immunohistochemistry (IHC)

Specificité: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogène: GRM5 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM5 (Human).

Information d'application

Indications d'application: GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-80 °C

Stockage commentaire: GRM5 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Détails sur Metabotropic Glutamate Receptor 5

Antigène: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Autre désignation: GRM5 (GRM5 Produits)

Synonymes: anticorps GPRC1E, anticorps MGLUR5, anticorps mGlu5, anticorps mGluR5, anticorps mGlur5, anticorps 6430542K11Rik, anticorps AI850523, anticorps Glu5R, anticorps Gprc1e, anticorps mGluR5b, anticorps glutamate receptor, metabotropic 5, anticorps glutamate metabotropic receptor 5, anticorps GRM5, anticorps Grm5

Sujet: Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia

ID gène: 2915

UniProt: P41594

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity