HSPA4 anticorps (Atto 390)
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- Antigène Voir toutes HSPA4 Anticorps
- HSPA4 (Heat Shock 70kDa Protein 4 (HSPA4))
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Reactivité
- Hamster
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HSPA4 est conjugé à/à la Atto 390
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- Detects ~110 kDa.
- Réactivité croisée
- Boeuf (Vache), Hamster, Humain, Singe, Souris, Rat, Saccharomyces cerevisiae, Requin, Mouton
- Purification
- Protein A Purified
- Immunogène
- Synthetic peptide derived from the sequence of hamster HSP110, sequence identical to human and mouse
- Top Product
- Discover our top product HSPA4 Anticorps primaire
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- Indications d'application
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- WB (1:1000)
- IHC (1:100)
- optimal dilutions for assays should be determined by the user.
- Commentaires
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1 μg/ml of ABIN2481904 was sufficient for detection of HSP110 in 10 μg of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS pH 7.2, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Conjugated antibodies should be stored at 4°C
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- Antigène
- HSPA4 (Heat Shock 70kDa Protein 4 (HSPA4))
- Autre désignation
- HSP110 (HSPA4 Produits)
- Sujet
- HSP110 belongs to a family of large stress proteins known as the HSP110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied HSP70 family. They share 30-33 % amino acid identity, mostly in the conserved ATP-binding domain (1). HSP110 cooperates with HSP70 in protein folding in the eukaryotic cytosol (2). In mammals, HSP110 is constitutively expressed, but exhibits particularly high levels in the brain. Both HSP70 and HSP110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of HSP110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of HSP70 (3). Studies also suggest that HSP110 can be used in heat shock protein-based cancer immunotherapy (4).
- ID gène
- 10808
- NCBI Accession
- NP_006635
- UniProt
- Q92599
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