Calcineurin A anticorps (AA 264-283) (FITC)

N° du produit ABIN2481985

Détail du produit anti-Calcineurin A anticorps (FITC)

Antigène: Calcineurin A (CAN)

Épitope: AA 264-283

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calcineurin A est conjugé à/à la FITC

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Detects ~61 kDa.

Réactivité croisée: Chien, Humain, Souris, Lapin, Rat

Purification: Peptide Affinity Purified

Immunogène: Human Calcineurin A peptide (AA 264-283)

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:120)
• IHC (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN2481985 was sufficient for detection of Calcineurin A in 20 μg of Heat shock Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur Calcineurin A

Antigène: Calcineurin A (CAN)

Autre désignation: Calcineurin A (CAN Produits)

Synonymes: anticorps Cna, anticorps DDBDRAFT_0185021, anticorps DDBDRAFT_0217855, anticorps DDB_0185021, anticorps DDB_0217855, anticorps PPP3CC, anticorps CAN A1/PP2B, anticorps CG1455, anticorps CNA1, anticorps Can, anticorps Cana1, anticorps CnA, anticorps CnnA21EF, anticorps D14, anticorps DmCanA1-100B, anticorps Dmel\\CG1455, anticorps PP2B, anticorps PP2B 21EF, anticorps PpD14, anticorps canA, anticorps pMY4, anticorps calcineurin A, anticorps Calcineurin A, anticorps CaM-dependent protein phosphatase, catalytic subunit, anticorps protein phosphatase 3 catalytic subunit alpha, anticorps Calcineurin A1, anticorps protein phosphatase 3 catalytic subunit beta, anticorps Cna, anticorps NFIA_077970, anticorps ACLA_011200, anticorps PAS_chr3_0414, anticorps canA, anticorps PPP3CA, anticorps CanA1, anticorps PPP3CB

Sujet: Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59KDa) the active site and a Ca2+ binding unit, Calcineurin B (19-20KDa) the regulatory subunit(1). Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs(2). Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506 (3).

ID gène: 5530

UniProt: Q08209