Piccolo anticorps (HRP)

N° du produit ABIN2482400

Détail du produit anti-Piccolo anticorps (HRP)

Antigène: Piccolo (PIC)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Piccolo est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Detects ~550 kDa. No cross-reactivity to Bassoon.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein A Purified

Immunogène: Recombinant Full length Protein, BC001304.1

Information d'application

Indications d'application:

• WB (1:1000)
• IHC (1:400)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN2482400 was sufficient for detection of Piccolo in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur Piccolo

Antigène: Piccolo (PIC)

Autre désignation: Piccolo (PIC Produits)

Sujet: Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).

ID gène: 27445

NCBI Accession: NP_055325

UniProt: Q9Y6V0