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SHANK2 anticorps (AA 84-309) (APC)

SHANK2 Reactivité: Rat WB, IHC, IP, IF, ICC, AA Hôte: Souris Monoclonal N23b-49 (Formerly S23b-49) APC
N° du produit ABIN2484048
  • Antigène Voir toutes SHANK2 Anticorps
    SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))
    Épitope
    • 27
    • 15
    • 10
    • 8
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 84-309
    Reactivité
    • 45
    • 33
    • 33
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 47
    • 31
    • 1
    Souris
    Clonalité
    • 49
    • 30
    Monoclonal
    Conjugué
    • 27
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SHANK2 est conjugé à/à la APC
    Application
    • 72
    • 34
    • 29
    • 25
    • 20
    • 20
    • 16
    • 13
    • 13
    • 10
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    Specificité
    Detects ~160 kDa. Recognizes Shank1, 2 and 3.
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Protein G Purified
    Immunogène
    Fusion protein amino acids 84-309 of rat Shank2
    Clone
    N23b-49 (Formerly S23b-49)
    Isotype
    IgG1
    Top Product
    Discover our top product SHANK2 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN2484048 was sufficient for detection of Shank1-4 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))
    Autre désignation
    SHANK (SHANK2 Produits)
    Synonymes
    anticorps AUTS17, anticorps CORTBP1, anticorps CTTNBP1, anticorps ProSAP1, anticorps SHANK, anticorps SPANK-3, anticorps mKIAA1022, anticorps auts17, anticorps cortbp1, anticorps cttnbp1, anticorps prosap1, anticorps spank-3, anticorps shank2, anticorps MGC122482, anticorps CortBP1, anticorps Spank-3, anticorps SHANK2, anticorps SH3 and multiple ankyrin repeat domains 2, anticorps SH3 and multiple ankyrin repeat domains 2 L homeolog, anticorps SH3 and multiple ankyrin repeat domains protein 2, anticorps SHANK2, anticorps Shank2, anticorps shank2.L, anticorps shank2, anticorps LOC100438523
    Sujet
    Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
    ID gène
    171093
    UniProt
    Q9QX74
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