DLG4 anticorps (Biotin)

N° du produit ABIN2484832

Détail du produit anti-DLG4 anticorps (Biotin)

Antigène: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DLG4 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)

Specificité: Detects ~100 kDa. An additional protein of >100 kDa is also detected. Additional cross-reactive bands are detected at ~75 kDa and 50 kDa in rat and mouse samples.

Réactivité croisée: Boeuf (Vache), Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Recombinant rat PSD-95

Clone: 7E3

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml was sufficient for detection of PSD-95 on 20 μg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur DLG4

Antigène: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Autre désignation: PSD95 (DLG4 Produits)

Synonymes: anticorps 11, anticorps CG1725, anticorps CG1730, anticorps CPD, anticorps DLG, anticorps DLG-A, anticorps Discs-large, anticorps Dlg, anticorps Dlg-A, anticorps Dlg1, anticorps DlgA, anticorps Dmel\\CG1725, anticorps Drodlg, anticorps PSD95, anticorps SAP97, anticorps anon-EST:Posey93, anticorps anon-WO03040301.258, anticorps anon-WO03040301.260, anticorps anon-WO03040301.268, anticorps d. lg.-1, anticorps dlg, anticorps dlg-1, anticorps dlg-A, anticorps dlgA, anticorps dlgS97, anticorps l(1)10Bf, anticorps l(1)G0276, anticorps l(1)G0342, anticorps l(1)G0456, anticorps l(1)G19, anticorps l(1)L11, anticorps l(1)bwn, anticorps l(1)d.lg-1, anticorps l(1)d.lg.-1, anticorps l(1)discs large, anticorps l(1)dlg, anticorps l(1)dlg-1, anticorps l(1)dlg1, anticorps l(1)l.pr.-2, anticorps l(1)lpr-2, anticorps misb, anticorps dlgh4, anticorps psd95, anticorps sap90, anticorps sap-90, anticorps LLGL1, anticorps Dlgh4, anticorps PSD-95, anticorps SAP90, anticorps SAP90A, anticorps Sap90, anticorps SAP-90, anticorps DLG4, anticorps discs large 1, anticorps discs, large homolog 4, anticorps discs large MAGUK scaffold protein 4, anticorps discs, large homolog 4b (Drosophila), anticorps discs, large homolog 4 (Drosophila), anticorps dlg1, anticorps dlg4, anticorps DLG4, anticorps dlg4b, anticorps Dlg4

Sujet: Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90 kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).

ID gène: 29495

NCBI Accession: NP_062567

UniProt: P31016

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity