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SHANK3 anticorps (AA 840-857) (Biotin)

SHANK3 Reactivité: Rat WB, IHC, IP, IF, ICC, AA Hôte: Souris Monoclonal S69 Biotin
N° du produit ABIN2485412
  • Antigène Voir toutes SHANK3 Anticorps
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    Épitope
    • 15
    • 10
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 840-857
    Reactivité
    • 43
    • 11
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 26
    • 21
    Souris
    Clonalité
    • 26
    • 21
    Monoclonal
    Conjugué
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SHANK3 est conjugé à/à la Biotin
    Application
    • 31
    • 27
    • 22
    • 21
    • 16
    • 13
    • 13
    • 9
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    Specificité
    Detects ~190 kDa. No cross-reactivity against Shank1 or Shank2.
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Protein G Purified
    Immunogène
    Synthetic peptide amino acids 840-857 of rat Shank3
    Clone
    S69
    Isotype
    IgG2b
    Top Product
    Discover our top product SHANK3 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN2485412 was sufficient for detection of Shank3 in 10 μg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    Autre désignation
    SHANK3 (SHANK3 Produits)
    Synonymes
    anticorps DEL22q13.3, anticorps PROSAP2, anticorps PSAP2, anticorps SCZD15, anticorps SPANK-2, anticorps Prosap2, anticorps AI841104, anticorps Shank3b, anticorps SH3 and multiple ankyrin repeat domains 3, anticorps SH3 and multiple ankyrin repeat domains protein 3, anticorps SHANK3, anticorps shank3, anticorps Shank3
    Sujet
    Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling, specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (2). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (3).
    ID gène
    59312
    NCBI Accession
    NP_067708
    UniProt
    Q9JLU4
    Pathways
    Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
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