Erythrocyte Ankyrin anticorps (AA 1-1881) (Biotin)

N° du produit ABIN2485532

Détail du produit anti-Erythrocyte Ankyrin anticorps (Biotin)

Antigène: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Épitope: AA 1-1881

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Erythrocyte Ankyrin est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Detects ~200 kDa. Does not cross-react with Ankyrin-B or Ankyrin-G.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R

Clone: S388A-10

Isotype: IgG2b

Information d'application

Indications d'application:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:100 dilution of ABIN2485532 was sufficient for detection of Ankyrin R in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur Erythrocyte Ankyrin

Antigène: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Autre désignation: Ankyrin R (ANK1 Produits)

Synonymes: anticorps CHANK1, anticorps wu:fa09h06, anticorps zgc:101835, anticorps ank, anticorps sph1, anticorps sph2, anticorps ANK1, anticorps ANK, anticorps SPH1, anticorps SPH2, anticorps Ank-1, anticorps nb, anticorps pale, anticorps ankyrin 1, anticorps ankyrin 1, erythrocytic a, anticorps ankyrin 1 L homeolog, anticorps ankyrin 1, erythrocytic, anticorps ankyrin 1, erythroid, anticorps ANK1, anticorps ank1a, anticorps ank1, anticorps ank1.L, anticorps Ank1

Sujet: Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).

ID gène: 286

NCBI Accession: NP_000028

UniProt: P16157

Pathways: Synaptic Membrane