Glutamate Receptor 1 anticorps (AA 1-389) (PE)

N° du produit ABIN2485608

Détail du produit anti-Glutamate Receptor 1 anticorps (PE)

Antigène: Glutamate Receptor 1 (GLUR1)

Épitope: AA 1-389

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Glutamate Receptor 1 est conjugé à/à la PE

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Detects ~100 kDa. Does not cross-react with GluR2.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1

Clone: S355-1

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN2485608 was sufficient for detection of GluA1/GluR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur Glutamate Receptor 1

Antigène: Glutamate Receptor 1 (GLUR1)

Autre désignation: GluR1 (GLUR1 Produits)

Sujet: Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3).

ID gène: 50592

NCBI Accession: NP_113796

UniProt: P19490

Pathways: Signalisation PI3K-Akt