SPTBN4 anticorps (AA 1621-1832)

N° du produit ABIN2485663

Détail du produit anti-SPTBN4 anticorps

Antigène: SPTBN4 (Spectrin Beta, Non-Erythrocytic 4 (SPTBN4))

Épitope: AA 1621-1832

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SPTBN4 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Detects ~>200 kDa. Does not cross react with other Beta-spectrins

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin

Clone: S393-2

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:100 dilution of ABIN2485663 was sufficient for detection of Beta 4 Spectrin in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Détails sur SPTBN4

Antigène: SPTBN4 (Spectrin Beta, Non-Erythrocytic 4 (SPTBN4))

Autre désignation: beta 4 Spectrin (SPTBN4 Produits)

Sujet: Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart (1). Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier (2).

ID gène: 57731

NCBI Accession: NP_066022

UniProt: Q9H254

Pathways: Sensory Perception of Sound, Regulation of Actin Filament Polymerization, Maintenance of Protein Location