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HSPB2 anticorps (Biotin)

HSPB2 Reactivité: Humain WB, IF, ICC Hôte: Lapin Polyclonal Biotin
N° du produit ABIN2486040
  • Antigène Voir toutes HSPB2 Anticorps
    HSPB2 (Heat Shock 27kDa Protein 2 (HSPB2))
    Reactivité
    • 39
    • 27
    • 27
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 54
    • 2
    Lapin
    Clonalité
    • 54
    • 2
    Polyclonal
    Conjugué
    • 26
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HSPB2 est conjugé à/à la Biotin
    Application
    • 43
    • 15
    • 14
    • 14
    • 13
    • 13
    • 13
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Detects ~27 kDa.
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Protein A Purified
    Immunogène
    Synthetic peptide
    Top Product
    Discover our top product HSPB2 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN2486040 was sufficient for detection of MKBP in 10 μg of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.02 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    HSPB2 (Heat Shock 27kDa Protein 2 (HSPB2))
    Autre désignation
    HSPB2 (HSPB2 Produits)
    Synonymes
    anticorps zgc:112532, anticorps HSP27, anticorps Hs.78846, anticorps LOH11CR1K, anticorps MKBP, anticorps 27kDa, anticorps 2810021G24Rik, anticorps heat shock protein family B (small) member 2, anticorps heat shock protein, alpha-crystallin-related, b2, anticorps heat shock protein 2, anticorps HSPB2, anticorps hspb2, anticorps Hspb2
    Sujet
    HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30 % sequence identity to all other mammalian sHSPS (1). MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique nature compared to other sHSPs, in that the expression of MKBP is not induced by heat shock (2). In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction (1, 3). During stress, these complexes dissolve and MKBP's localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic (1). HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis (4).
    ID gène
    3316
    NCBI Accession
    NP_001532
    UniProt
    Q16082
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