SOD1 anticorps (N-Term) (APC)

N° du produit ABIN2486242

Détail du produit anti-SOD1 anticorps (APC)

Antigène: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOD1 est conjugé à/à la APC

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Recognizes a conformation specific epitope where the beta barrel is unfolded.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein A Purified

Immunogène: Within 50 AA of N-terminal region of SOD1, unfolded beta barrel region

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1μg/ml of ABIN2486242 was sufficient for detection of the unfolded beta barrel of SOD1 by colorimetric dot blot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur SOD1

Antigène: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Autre désignation: SOD1 (SOD1 Produits)

Synonymes: anticorps LOC692639, anticorps ALS, anticorps ALS1, anticorps IPOA, anticorps SOD, anticorps hSod1, anticorps homodimer, anticorps CG11793, anticorps Cu, anticorps Cu-Zn SOD, anticorps Cu/Zn SOD, anticorps Cu/Zn sod, anticorps Cu/Zn superoxide dismutase, anticorps Cu/ZnSOD, anticorps CuSOD, anticorps CuZn SOD, anticorps CuZn-SOD, anticorps CuZn-SOD1, anticorps CuZnSOD, anticorps Cu[2+]/Zn[2+]SOD, anticorps Dmel\\CG11793, anticorps G, anticorps Mn SOD, anticorps SOD-1, anticorps SOD1, anticorps Sod-1, anticorps Sod1, anticorps To, anticorps To-1, anticorps Zn SOD, anticorps Zn Sod, anticorps Zn-SOD, anticorps ZnSod, anticorps cSOD, anticorps cSod, anticorps dSOD1, anticorps l(3)108, anticorps l(3)68Af', anticorps l(3)G, anticorps sod, anticorps sod1, anticorps CU/ZN-SOD, anticorps SODC, anticorps DKFZP469M1833, anticorps B430204E11Rik, anticorps Cu/Zn-SOD, anticorps Ipo-1, anticorps Ipo1, anticorps SOD1L1, anticorps XSODB, anticorps als, anticorps als1, anticorps ipoa, anticorps sod1-a, anticorps ZSOD, anticorps cuzn, anticorps Cu/Zn superoxide dismutase, anticorps superoxide dismutase 1, anticorps Superoxide dismutase 1, anticorps superoxide dismutase 1, soluble, anticorps superoxide dismutase 1 S homeolog, anticorps Superoxide dismutase [Cu-Zn], anticorps superoxide dismutase 1 L homeolog, anticorps superoxide dismutase [Cu-Zn]-like, anticorps superoxide dismutase [Cu-Zn], anticorps superoxide dismutase Sod1, anticorps SOD, anticorps SOD1, anticorps Sod1, anticorps sod1, anticorps sod1.S, anticorps sod-1, anticorps sod1.L, anticorps LOC101451855, anticorps LOC101115136

Sujet: Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (2). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4). In general, SODs play a major role in antioxidant defense mechanisms (3). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (2). Misfolding of SOD1 has been implicated in Amyotrophic lateral sclerosis (ALS). Therefore conformation specific antibodies such as Anti-SOD1 (UbetaB), which targets an unfolded region of the beta barrel of SOD1, are useful for determining the conformation of SOD1 in affected tissues (5). This antibody can be used in conjunction with Anti-SOD1 (EDI) (SPC-206D) which detects an exposed dimer interface (EDI) of SOD1.

ID gène: 6647

UniProt: P00441

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis