SLC12A3 anticorps (AA 74-95) (Atto 594)
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- Antigène Voir toutes SLC12A3 Anticorps
- SLC12A3 (Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3))
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Épitope
- AA 74-95
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Reactivité
- Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SLC12A3 est conjugé à/à la Atto 594
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoelectron Microscopy (IEM), Immunofluorescence (IF)
- Specificité
- Detects ~160 kDa.
- Réactivité croisée
- Chien, Humain, Souris, Rat
- Purification
- Affinity Purified
- Immunogène
- Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal
- Top Product
- Discover our top product SLC12A3 Anticorps primaire
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- Indications d'application
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- WB (1:1000)
- IHC (1:200)
- optimal dilutions for assays should be determined by the user.
- Commentaires
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1 μg/ml of ABIN2486285 was sufficient for detection of NCC3 in 10 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Conjugated antibodies should be stored at 4°C
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- Antigène
- SLC12A3 (Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3))
- Autre désignation
- NCC (SLC12A3 Produits)
- Synonymes
- anticorps SLC12A3, anticorps slc12a3, anticorps DKFZp469N2315, anticorps NCC, anticorps NCCT, anticorps TSC, anticorps AI035291, anticorps solute carrier family 12 member 3, anticorps solute carrier family 12 (sodium/chloride transporter), member 3, anticorps solute carrier family 12, member 3, anticorps SLC12A3, anticorps slc12a3.2, anticorps Slc12a3
- Sujet
- NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis (1). Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC (2). Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat (3).
- ID gène
- 54300, 6559
- NCBI Accession
- NP_062218, NP_000330
- UniProt
- P55018, P55017
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