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FKBP4 anticorps (APC)

FKBP4 Reactivité: Humain WB, IHC, IP, IF, ICC Hôte: Souris Monoclonal Hi52C APC
N° du produit ABIN2486528
  • Antigène Voir toutes FKBP4 Anticorps
    FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
    Reactivité
    • 100
    • 32
    • 16
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 63
    • 35
    • 2
    Souris
    Clonalité
    • 59
    • 41
    Monoclonal
    Conjugué
    • 47
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FKBP4 est conjugé à/à la APC
    Application
    • 82
    • 48
    • 37
    • 26
    • 18
    • 16
    • 15
    • 15
    • 14
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Detects ~52 kDa. Heavy chain migrates close to FKBP52 on SDS PAGE.
     Réactivité croisée
    Chien, Hamster, Humain, Souris, Rat
    Purification
    Protein G Purified
    Immunogène
    Synthetic peptide corresponding to the residues of human FKBP52
    Clone
    Hi52C
    Isotype
    IgG2a
    Top Product
    Discover our top product FKBP4 Anticorps primaire
  • Indications d'application
    • WB (1:2000)
    • IHC (1:250)
    • ICC/IF (1:1000)
    • IP (5 μg)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    0.5 μg/ml was sufficient for detection of FKBP52 in 20 μg total protein using WB by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
    Autre désignation
    FKBP52 (FKBP4 Produits)
    Synonymes
    anticorps HBI, anticorps p52, anticorps hsp56, anticorps PPIase, anticorps fkbp52, anticorps fkbp59, anticorps MGC81078, anticorps wu:fb34f09, anticorps 59kDa, anticorps AL022792, anticorps AW208983, anticorps FKBP-4, anticorps FKBP-52, anticorps FKBP52, anticorps FKPB52, anticorps p59, anticorps FKBP51, anticorps FKBP59, anticorps Hsp56, anticorps P59, anticorps FK506 binding protein 4, anticorps FK506 binding protein 4 S homeolog, anticorps FKBP4, anticorps fkbp4.S, anticorps fkbp4, anticorps Fkbp4
    Sujet
    HSP90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of HSP90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an HSP90 binding site. Among the TPR cochaperones of HSP90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the HSP90 (4). Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different HSP90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).
    ID gène
    2288
    NCBI Accession
    NP_002005
    UniProt
    Q02790
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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