Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

HSPB8 anticorps (APC)

HSPB8 Reactivité: Humain WB, IHC, IF, IP, ICC Hôte: Lapin Polyclonal APC
N° du produit ABIN2486740
  • Antigène Voir toutes HSPB8 Anticorps
    HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))
    Reactivité
    • 91
    • 35
    • 22
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 67
    • 23
    • 1
    Lapin
    Clonalité
    • 63
    • 28
    Polyclonal
    Conjugué
    • 40
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HSPB8 est conjugé à/à la APC
    Application
    • 69
    • 34
    • 26
    • 25
    • 24
    • 14
    • 13
    • 11
    • 10
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificité
    Detects ~22 kDa. Does not cross-react with HSP27 or alpha-crystallin.
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Peptide Affinity Purified
    Immunogène
    Human HSP22
    Top Product
    Discover our top product HSPB8 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • ICC/IF (1:100)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    A 1:1000 dilution of ABIN2486740 was sufficient for detection of HSP22 in 10 μg of rat tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))
    Autre désignation
    HSP22 (HSPB8 Produits)
    Synonymes
    anticorps CMT2L, anticorps DHMN2, anticorps E2IG1, anticorps H11, anticorps HMN2, anticorps HMN2A, anticorps HSP22, anticorps MGC64408, anticorps hsc70, anticorps wu:fb01g06, anticorps wu:fi48b06, anticorps fc09c11, anticorps wu:fc04b04, anticorps wu:fc09c11, anticorps zgc:64202, anticorps AU018630, anticorps AW413033, anticorps Cryac, anticorps D5Ucla4, anticorps H11K, anticorps HSP20-like, anticorps Hsp22, anticorps heat shock protein family B (small) member 8, anticorps heat shock protein family B (small) member 8 L homeolog, anticorps heat shock protein 8, anticorps heat shock protein b8, anticorps HSPB8, anticorps hspb8.L, anticorps hspa8, anticorps hspb8, anticorps Hspb8
    Sujet
    HSP22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to HSP27. Similar to most other sHSPs, HSP22 is predominately transcribed in skeletal muscle and heart, as well as the placenta (1). HSP22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HSPB8 interacted preferentially with a triple aspartate form of HSP27 which mimics HSP27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type HSP27 (2). HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs (3). The chaperone-like activity is of great importance to the function of HSP22 in various processes including proliferation, apoptosis and macro autophagy (4). Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) (5).
    ID gène
    26353
    NCBI Accession
    NP_055180
    UniProt
    Q9UJY1
Vous êtes ici:
Support technique