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CILP anticorps (AA 1051-1184)

CILP Reactivité: Humain, Rat WB, ELISA, FACS, ICC, IF (cc), IF (p), IHC (fro), IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2559699
  • Antigène Voir toutes CILP Anticorps
    CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
    Épitope
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1051-1184
    Reactivité
    • 25
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    • 19
    • 4
    • 2
    • 2
    Lapin
    Clonalité
    • 24
    • 3
    Polyclonal
    Conjugué
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CILP est non-conjugé
    Application
    • 24
    • 13
    • 12
    • 12
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    The immunogen falls within the Cartilage intermediate layer protein 1 C2 region.
     Réactivité croisée
    Humain, Rat
    Homologie
    Mouse,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human CILP
    Isotype
    IgG
    Top Product
    Discover our top product CILP Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
    Autre désignation
    CILP (CILP Produits)
    Synonymes
    anticorps CILP-1, anticorps HsT18872, anticorps 9830114D16, anticorps C130036G17Rik, anticorps NTPPH, anticorps CILP, anticorps im:7137994, anticorps cartilage intermediate layer protein, anticorps cartilage intermediate layer protein, nucleotide pyrophosphohydrolase, anticorps cartilage intermediate layer protein 1, anticorps CILP, anticorps Cilp, anticorps cilp, anticorps LOC100336614
    Sujet

    Synonyms: CILP-1, HsT18872, Cartilage intermediate layer protein 1, Cartilage intermediate-layer protein, CILP, UNQ602/PRO1188

    Background: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

    ID gène
    8483
    UniProt
    O75339
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