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Bovine Coronavirus anticorps

BCoV Reactivité: Bovine Coronavirus (BCoV) EIA Hôte: Souris Monoclonal 5A4 unconjugated
N° du produit ABIN263581
  • Antigène Tous les produits Bovine Coronavirus (BCoV)
    Bovine Coronavirus (BCoV)
    Reactivité
    Bovine Coronavirus (BCoV)
    Hôte
    • 4
    Souris
    Clonalité
    • 3
    Monoclonal
    Conjugué
    • 4
    Cet anticorp Bovine Coronavirus est non-conjugé
    Application
    • 4
    • 2
    • 1
    Enzyme Immunoassay (EIA)
    Attributs du produit
    Synonyms: Spike glycoprotein, S glycoprotein
    Purification
    Protein G chromatography
    Pureté
    > 95 % pure (SDS-PAGE)
    Immunogène
    Bovine corona virus. Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/cmice.
    Clone
    5A4
    Isotype
    IgG1
  • Indications d'application
    ELISA. HIT (hemagglutination inhibition titer).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.8mg/mL (OD280nm E0.1%=1.4)
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
    Shelf life: one year from despatch.
    Date de péremption
    12 months
  • Antigène
    Bovine Coronavirus (BCoV)
    Abstract
    BCoV Produits
    Classe de substances
    Virus
    Sujet
    Bovine Corona Virus Spike glycoprotein is cleaved into S1 and S2 Spike proteins. The precursor is processed into S1 and S2 by host cell furin or furin-like protease to yield the mature S1 and S2 proteins. The cleavage site between S1 and S2 requires the optimal sequence [KR]-X-[KR]-R.S1 attaches the virion to the cell membrane by binding to 9-O-acetylated sialic acid containing proteins, initiating the infection.S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.Synonyms: E2 protein, Peplomer protein, S glycoprotein, Spike glycoprotein
    UniProt
    P25193
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