VSX2 anticorps (C-Term)

N° du produit ABIN265010

Détail du produit anti-VSX2 anticorps

Antigène: VSX2 (Visual System Homeobox 2 (VSX2))

Épitope: AA 264-361, C-Term

Reactivité: Souris, Rat

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp VSX2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody recognizes chx 10 (C-Term). Other species not tested.

Purification: Purified

Immunogène: Antibody raised against a recombinant protein corresponding to amino acids 264 to 361 derived from the C terminal of the human Chx10 protein conjugated to GST.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 0.5-1.0 mg/mL. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS containing 0.08 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C. Can be shipped at ambient temperature.

Références pour anticorps anti-VSX2 (ABIN265010)

Francius, Harris, Rucchin, Hendricks, Stam, Barber, Kurek, Grosveld, Pierani, Goulding, Clotman: "Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord." dans: PLoS ONE, Vol. 8, Issue 8, pp. e70325, (2013) (PubMed).

Nittner, Lambertz, Clermont, Mestdagh, Köhler, Nielsen, Jochemsen, Speleman, Vandesompele, Dyer, Schramm, Schulte, Marine: "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." dans: Nature cell biology, Vol. 14, Issue 9, pp. 958-65, (2012) (PubMed).

Qiu, Jiang, Xiang: "A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 13, pp. 3392-403, (2008) (PubMed).

Elshatory, Everhart, Deng, Xie, Barlow, Gan: "Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 46, pp. 12707-20, (2007) (PubMed).

Osakada, Ooto, Akagi, Mandai, Akaike, Takahashi: "Wnt signaling promotes regeneration in the retina of adult mammals." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 15, pp. 4210-9, (2007) (PubMed).

Détails sur VSX2

Antigène: VSX2 (Visual System Homeobox 2 (VSX2))

Autre désignation: VSX2 / CHX10 (VSX2 Produits)

Synonymes: anticorps CHX10, anticorps HOX10, anticorps MCOP2, anticorps MCOPCB3, anticorps RET1, anticorps Chx10, anticorps Hox-10, anticorps Hox10, anticorps or, anticorps VSX2, anticorps Vsx-2, anticorps alx, anticorps chx10, anticorps c-ret, anticorps cret, anticorps etID315074.13, anticorps ret1, anticorps wu:fd13h01, anticorps visual system homeobox 2, anticorps ret proto-oncogene receptor tyrosine kinase, anticorps Vsx2 transcription factor, anticorps VSX2, anticorps Vsx2, anticorps vsx2, anticorps ret

Sujet: Chx10 is a 46 kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.Synonyms: Ceh-10 homeodomain-containing homolog, HOX10, Homeobox protein CHX10, Visual system homeobox 2

Poids moléculaire: 46 kDa

ID gène: 12677

NCBI Accession: NP_031727

UniProt: Q61412

Pathways: Dopaminergic Neurogenesis