TYROBP
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western Blot. Immunoprecipitation: Use 2-4 μg/mL of protein lysate. Positive Control: NKp44 positive cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS, 0.08 % Sodium Azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
Antigène
TYROBP
(TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).Synonyms: DNAX-activation protein 12, KARAP, Killer-activating receptor-associated protein, TYRO protein tyrosine kinase-binding protein