ATF2 anticorps
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- Antigène Voir toutes ATF2 Anticorps
- ATF2 (Activating Transcription Factor 2 (ATF2))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ATF2 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of ATF2 protein. (region surrounding Val63)
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Affinity chromatography
- Pureté
- > 95 % pure SDS-PAGE
- Top Product
- Discover our top product ATF2 Anticorps primaire
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- Indications d'application
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IP: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- ATF2 (Activating Transcription Factor 2 (ATF2))
- Autre désignation
- ATF2 (ATF2 Produits)
- Synonymes
- anticorps CRE-BP1, anticorps CREB2, anticorps HB16, anticorps TREB7, anticorps CG12850, anticorps CG3749, anticorps dATF-2, anticorps DmelCG30420, anticorps CG30420, anticorps CHN1, anticorps Atf-2, anticorps CRE-BP, anticorps Creb2, anticorps D130078H02Rik, anticorps D18875, anticorps Tg(Gzma-Klra1)7Wum, anticorps mXBP, anticorps atf2-A, anticorps atf2l, anticorps activating transcription factor 2, anticorps Activating transcription factor-2, anticorps activating transcription factor 2 S homeolog, anticorps ATF2, anticorps Atf-2, anticorps Atf2, anticorps atf2.S, anticorps atf2
- Sujet
- The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins (1). ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2. Mutations of these sites result in the loss of stress-induced transcription by ATF-2. In addition, mutations at these sites reduce the ability of E1A and Rb to stimulate gene expression via ATF-2.Synonyms: ATF-2, Activating transcription factor 2, CRE-BP1, CREB-2, CREB2, CREBP1, Cyclic AMP-dependent transcription factor ATF-2, Cyclic AMP-responsive element-binding protein 2, HB16, cAMP response element-binding protein CRE-BP1, cAMP-dependent transcription factor ATF-2
- Poids moléculaire
- approx. 55 to 75 kDa
- ID gène
- 1386
- NCBI Accession
- NP_001871
- UniProt
- P15336
- Pathways
- Signalisation MAPK, Signalisation RTK, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades
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