ELISA: 1/10000approx. 1/20000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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anticorps CK16, anticorps FNEPPK, anticorps K16, anticorps K1CP, anticorps KRT16A, anticorps NEPPK, anticorps AI324768, anticorps Krt1-16, anticorps Ka16, anticorps KRT16, anticorps Krt16, anticorps keratin 16, anticorps keratin 16, type I S homeolog, anticorps keratin, type I cytoskeletal 16, anticorps KRT16, anticorps Krt16, anticorps krt16.S, anticorps LOC101108147, anticorps LOC100714013
Sujet
Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10 % of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. Two cytokeratins, 6 and 16, are expressed when keratincytes are undergoing rapid turnover in various pathological states, wound healing, psoriasis and some carcinomasSynonyms: CK16, Cytokeratin-16, K16, KRT16, KRT16A, Keratin 16, Keratin type I cytoskeletal 16, Keratin-16