IKZF3 anticorps (Alexa Fluor 647)

N° du produit ABIN2657113

Détail du produit anti-IKZF3 anticorps (Alexa Fluor 647)

Antigène: IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IKZF3 est conjugé à/à la Alexa Fluor 647

Application: Flow Cytometry (FACS)

Aucune reactivité croisée: Souris

Purification: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.

Clone: 8B2

Isotype: IgG1 kappa, IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C

Détails sur IKZF3

Antigène: IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

Autre désignation: Aiolos (IKZF3 Produits)

Synonymes: anticorps AIO, anticorps AIOLOS, anticorps ZNFN1A3, anticorps aio, anticorps aiolos, anticorps znfn1a3, anticorps IKZF3, anticorps 5830411O07Rik, anticorps Aiolos, anticorps Zfpn1a3, anticorps Znfn1a3, anticorps IKAROS family zinc finger 3, anticorps IKAROS family zinc finger 3 L homeolog, anticorps IKZF3, anticorps ikzf3.L, anticorps Ikzf3

Sujet: Aiolos, an Ikaros family member, is also known as Izkf3. It has a molecular weight of 58 kD and shows 70 % homology to the Ikaros isoform, Ik-1, particularly in the DNA binding and C-terminal domains. Aiolos can form a heteromer with Ikaros or exist as a homodimer. The homomeric complex is a potent transcriptional activator. Unlike Ikaros, Aiolos is expressed in late fetal thymus and adult lymphoid organs. Among the adult hematopoietic progenitors, Aiolos is expressed at low levels in mulitpotent but not in pluripotent stem cells. When these multipotent progenitors become more restricted to T and B lymphoid pathways there is an upregulation in Aiolos expression. The highest expression of Aiolos is detected in the spleen (especially in B-cells) followed by thymus and bone marrow, and cannot be detected in the non-lymphoid organs. Aiolos plays an important role in lymphocyte proliferation and differentiation.