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LRRC32 anticorps (Alexa Fluor 647)

LRRC32 Reactivité: Souris FACS Hôte: Rat Monoclonal F011-5 Alexa Fluor 647
N° du produit ABIN2657200
  • Antigène Voir toutes LRRC32 Anticorps
    LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
    Reactivité
    • 30
    • 12
    • 9
    • 1
    Souris
    Hôte
    • 20
    • 16
    • 3
    • 1
    Rat
    Clonalité
    • 21
    • 19
    Monoclonal
    Conjugué
    • 21
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    Cet anticorp LRRC32 est conjugé à/à la Alexa Fluor 647
    Application
    • 20
    • 16
    • 15
    • 10
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Purification
    The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
    Clone
    F011-5
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product LRRC32 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect from prolonged exposure to light. Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C
  • Antigène
    LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
    Autre désignation
    GARP (LRRC32 Produits)
    Synonymes
    anticorps D11S833E, anticorps GARP, anticorps AI426318, anticorps D11S833Eh, anticorps D7H11S833E, anticorps EG434215, anticorps Garp, anticorps leucine rich repeat containing 32, anticorps LRRC32, anticorps Lrrc32
    Sujet
    Glycoprotein A Repetitions Predominant (GARP), also known as leucine rich repeat containing protein 32 (LRC32), is a 80 kD type I membrane glycoprotein with 20 leucine rich repeats in the extracellular portion of the protein. GARP was found on the surface of megakaryocytes, platelets, and activated Tregs. It serves as a receptor for latent TGF-β. Recent evidence suggests that GARP may play a role in controlling suppressor function of Tregs. A mutation in GARP has been reported in a large Samaritan kindred with Usher syndrome type 1. In addition, it has been found that GARP mRNA is highly amplified in different tumors, which indicates that tumor cells may use GARP to express TGF-β or to capture TGF-β from their surroundings, resulting in local suppression of anti-tumor immune responses or the induction of Tregs.
    Pathways
    Activated T Cell Proliferation
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