IKZF2 anticorps (Alexa Fluor 488)

N° du produit ABIN2657510

Détail du produit anti-IKZF2 anticorps (Alexa Fluor 488)

Antigène: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Reactivité: Humain, Souris

Hôte: Hamster arménien

Clonalité: Monoclonal

Conjugué: Cet anticorp IKZF2 est conjugé à/à la Alexa Fluor 488

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.

Clone: 22F6

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C

Détails sur IKZF2

Antigène: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Autre désignation: Helios (IKZF2 Produits)

Synonymes: anticorps ANF1A2, anticorps HELIOS, anticorps ZNF1A2, anticorps ZNFN1A2, anticorps helios, anticorps znf1a2, anticorps znfn1a1, anticorps znfn1a2, anticorps IKZF2, anticorps MGC159581, anticorps DKFZp469N0319, anticorps A730095J18Rik, anticorps Helios, anticorps Zfpn1a2, anticorps Znfn1a2, anticorps ikzf2, anticorps znfn1a1-a, anticorps IKAROS family zinc finger 2, anticorps si:zfos-1425h8.1, anticorps IKAROS family zinc finger 2 (Helios), anticorps IKAROS family zinc finger 2 L homeolog, anticorps IKZF2, anticorps ikzf2, anticorps Ikzf2, anticorps si:zfos-1425h8.1, anticorps ikzf2.L

Sujet: Helios is a member of the Ikaros family of zinc finger transcription factors. It contains a C-terminal region composed of 2 zinc-finger domains that mediate dimerization between the family members. Helios was originally cloned from a mouse thymoma line. It is mainly expressed in peripheral T cells and thymocytes. It is found at high levels in a subpopulation of regulatory T cells. Helios plays an important role in T cell development and homeostasis. Overexpression of Helios profoundly alters αβ T cell differentiation and activation. It has been determined that silencing of Helios in B cells is critical for maintaining normal B cell function. Helios is also involved in tumor immunity.