GATA3 anticorps (APC)
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- Antigène Voir toutes GATA3 Anticorps
- GATA3 (GATA Binding Protein 3 (GATA3))
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp GATA3 est conjugé à/à la APC
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Application
- Flow Cytometry (FACS)
- Purification
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
- Clone
- 16E10A23
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product GATA3 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from prolonged exposure to light. Do not freeze.
- Stock
- 4 °C
- Stockage commentaire
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Antigène
- GATA3 (GATA Binding Protein 3 (GATA3))
- Autre désignation
- GATA3 (GATA3 Produits)
- Synonymes
- anticorps HDR, anticorps HDRS, anticorps Gata-3, anticorps jal, anticorps cb550, anticorps gta3, anticorps GATA-3, anticorps XGATA3, anticorps xgata-3, anticorps hdr, anticorps xGATA-3, anticorps GATA3, anticorps GATA transcription factor 3, anticorps T4L20.260, anticorps T4L20_260, anticorps gata3, anticorps ZH-DR, anticorps zgc:103531, anticorps GATA binding protein 3, anticorps GATA binding protein 3 S homeolog, anticorps GATA transcription factor 3, anticorps amidase, anticorps putative amidase, anticorps GATA-binding protein 3, anticorps hematopoietic death receptor, anticorps GATA3, anticorps Gata3, anticorps gata3, anticorps gata3.S, anticorps gatA3, anticorps hdr
- Sujet
- GATA3 functions as a major regulator of T helper 2 (Th2) cell differentiation in immune cells. GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible for preferential differentiation of Th2-cells. GATA3 has been shown to regulate early developmental processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T cell survival. In the mammary gland, GATA3 plays an important role in differentiation and commitment of luminal epithelial cells. In a mouse model, exogenous expression of GATA3 in undifferentiated breast carcinoma cells induces differentiation and suppresses spreading of the tumor cells, suggesting that GATA3 is involved in preventing malignancy of breast cancer. GATA3 has been reported to be essential in the development of a variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR syndrome).
- Pathways
- Hormone Transport, Regulation of Hormone Metabolic Process, Tube Formation
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