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SIGLEC8 anticorps (APC)

SIGLEC8 Reactivité: Humain FACS, ICFC Hôte: Souris Monoclonal 7C9 APC
N° du produit ABIN2658389
  • Antigène Voir toutes SIGLEC8 Anticorps
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Reactivité
    • 42
    • 6
    • 2
    Humain
    Hôte
    • 32
    • 9
    • 1
    Souris
    Clonalité
    • 34
    • 8
    Monoclonal
    Conjugué
    • 23
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SIGLEC8 est conjugé à/à la APC
    Application
    • 32
    • 20
    • 19
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
    Purification
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Clone
    7C9
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product SIGLEC8 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect from prolonged exposure to light. Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Antigène
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Autre désignation
    Siglec-8 (SIGLEC8 Produits)
    Synonymes
    anticorps SAF2, anticorps SIGLEC-8, anticorps SIGLEC8L, anticorps SIGLEC8, anticorps sialic acid binding Ig like lectin 8, anticorps sialic acid-binding Ig-like lectin 8, anticorps SIGLEC8, anticorps LOC506364
    Sujet
    Siglec-8 is a lectin specific for 6'-sulfo-sLex and a member of the Ig-superfamily. It is expressed almost exclusively in eosinophils, however, basophils and mast cells can express it to a lower degree. Siglec-8 is a 54 kD transmembranal protein, the extracellular domain has one V-set Ig-like domain and two C2-set domains. The cytoplasmic domain has two immunoreceptor tyrosine-based inhibitor motifs (ITIM) that recruit SH2-family phosphatases after tyrosine phosphorylation. There are reports that siglec-8 inhibits the release of histamine and prostaglandin D2 mediated by the IgEFcR. This molelcule is also involved in the induction of apoptosis.
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