IL-22 anticorps (Ala34) (Biotin)
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- Antigène Voir toutes IL-22 (IL22) Anticorps
- IL-22 (IL22) (Interleukin 22 (IL22))
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Épitope
- Ala34
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Reactivité
- Humain
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IL-22 est conjugé à/à la Biotin
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Application
- Flow Cytometry (FACS)
- Réactivité croisée (Details)
- In sandwich ELISA, less than 10 % cross-reactivity with recombinant mouse IL-22.
- Purification
- The antibody was purified by antigen affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
- Immunogène
- Ala34-Isoleucin179 (Accession# NM_020525) was expressed in E. coli.
- Clone
- Poly5161
- Isotype
- Ig Fraction, IgG
- Top Product
- Discover our top product IL22 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Do not freeze.
- Stock
- 4 °C
- Stockage commentaire
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Antigène
- IL-22 (IL22) (Interleukin 22 (IL22))
- Autre désignation
- IL-22 (IL22 Produits)
- Synonymes
- anticorps IL-21, anticorps IL-22, anticorps IL-D110, anticorps IL-TIF, anticorps ILTIF, anticorps TIFIL-23, anticorps TIFa, anticorps zcyto18, anticorps IL-22a, anticorps ILTIFa, anticorps Iltif, anticorps RGD1561292, anticorps interleukin-22, anticorps interleukin 22, anticorps IL22, anticorps il22, anticorps Il22
- Sujet
- IL-22 is a cytokine structurally related to IL-10. Originally identified as a murine gene induced by IL-9 in T and mast cells, IL-22 was initially designated ILTIF (IL-10-related T cell-derived inducible factor). IL-22 belongs to a family of cytokines with limited homology to IL-10, namely IL-10, IL-19, IL-20, IL-24, IL-26, and the IFN-λs, IL-28A, IL-28B and IL-29. Human IL-22 shares 79 % amino acid identity with murine IL-22 and 25 % identity with human IL-10. IL-22 biological activity is initiated by binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains. Activity is further regulated through interactions with the soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex belong to the class II CRF. Two types of IL-22 binding receptors have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. IL-22 is produced by Th17 cells and newly identified Th22 cells. It plays a critical role in mucosal immunity in addition to the deregulated inflammation observed in autoimmune diseases.
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