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TNFRSF18 anticorps (FITC)
TNFRSF18
Reactivité: Souris
FACS, WB, IHC
Hôte: Rat
Monoclonal
YGITR 765
FITC
N° du produit ABIN2661689
Détail du produit anti-TNFRSF18 anticorps (FITC)
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Antigène
Voir toutes TNFRSF18 Anticorps
TNFRSF18
(Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
Reactivité
Toutes les réactivités sur TNFRSF18 Anticorps
Souris
Hôte
Toutes les hôtes sur TNFRSF18 Anticorps
Rat
Clonalité
Toutes les clonalités sur TNFRSF18 Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers TNFRSF18 Anticorps
Cet anticorp TNFRSF18 est conjugé à/à la FITC
Application
Tous les applications à travers TNFRSF18 Anticorps.
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC)
Purification
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Clone
YGITR 765
Isotype
IgG2b kappa
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Protect from prolonged exposure to light. Do not freeze.
Stock
4 °C
Stockage commentaire
The antibody solution should be stored undiluted between 2°C and 8°C.
Détails sur TNFRSF18
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Antigène
TNFRSF18
(Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
Autre désignation
CD357 (TNFRSF18 Produits )
Synonymes
anticorps GITR, anticorps TNFRSF18, anticorps AITR, anticorps Gitr, anticorps CD357, anticorps GITR-D, anticorps TNF receptor superfamily member 18, anticorps tumor necrosis factor receptor superfamily, member 18, anticorps TNFRSF18, anticorps Tnfrsf18
Sujet
GITR, Glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD4+ CD25+ T regulatory (Treg) cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation, and abrogate the inhibitory functions of CD4+CD25+ Treg cells. In vivo activation GITR causes development of autoimmune diseases and restores the suppressed immune responses.
Pathways
Cancer Immune Checkpoints
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