Cet anticorp Fc epsilon RI/FCER1A est conjugé à/à la Pacific Blue
Application
ELISA
Purification
The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions. The solution is free of unconjugated Pacific Blue™.
anticorps FCER1A, anticorps FCE1A, anticorps FcERI, anticorps Iger01, anticorps RATIGER01, anticorps Fce1a, anticorps Fcr-5, anticorps fcepsilonri, anticorps Fc fragment of IgE receptor Ia, anticorps Fc receptor, IgE, high affinity I, alpha polypeptide, anticorps FCER1A, anticorps Fcer1a
Sujet
High affinity IgE receptor (FcεRI) plays a key role in IgE-mediated allergic immune response. FcεRI is a tetrameric receptor complex, which is composed of one α-subunit (FcεRIα), one β-subunit, and two γ-subunits. FcεRIα directly binds IgE with high affinity, while the β- and γ-chains are responsible for mediating intracellular signals. FcεRIα is a 50 kD transmembrane protein with Ig superfamily structure. It is primarily found on mast cells and basophils. Further studies have indicated that FcεRIα is also expressed on many inflammatory cells including cutaneuos Langerhans cells, dendritic cells, monocytes of patients with allergic disorders, platelets, bronchial epithelial cells, eosinophils produced in hypereosinophilic syndrome, and neutrophils from allergy-induced asthma patients.