Cet anticorp IL17 Receptor B est conjugé à/à la PE
Application
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family. IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R. It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells. It binds IL-17B and IL-17E (IL-25) but not IL-17A or C. Its interaction with IL-25 has a higher affinity than that with IL-17B. Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1. IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.