The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
anticorps VSIG9, anticorps VSTM3, anticorps WUCAM, anticorps ENSMUSG00000071552, anticorps Vstm3, anticorps RGD1563191, anticorps T-cell immunoreceptor with Ig and ITIM domains, anticorps T cell immunoreceptor with Ig and ITIM domains, anticorps TIGIT, anticorps Tigit
Sujet
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set and transmembrane domain-containing protein 3 (Vstm3), is a 26 kD, type I transmembrane protein and member of the CD28 family. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. Its ligands are PVR, PVRL2, PVRL3, CD155, and CD112. TIGIT is a negative regulator of NK and T cell activation. Engagement of TIGIT by dendritic cells results in their differentiation into a tolerogenic phenotype, with an increased secretion of IL-10 and a diminished production of IL-12. Mice deficient for TIGIT are more susceptible to autoimmune disease.