anticorps CD85K, anticorps ILT-3, anticorps ILT3, anticorps LIR-5, anticorps LIR5, anticorps Gp49b, anticorps HM18, anticorps gp49, anticorps leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4, anticorps leukocyte immunoglobulin like receptor B4, anticorps leukocyte immunoglobulin-like receptor, subfamily B, member 4A, anticorps LILRB4, anticorps Lilrb4a
Sujet
Gp49, also known as ILT3, gp49b1 or CD85k, is a 49 kD glycoprotein expressed on activated NK cells and myeloid cells. It structurally resembles killer inhibitory receptors (KIR). gp49B is a type I membrane protein belonging to the Ig superfamily and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), while gp49A is a truncated molecule without ITIM. Upon activation following interaction with integrin a vb3, the cytoplasmic tail associates with SHP-1 and SHP-2, which results in downregulation of cell activation and cytokine production.