DDX3X anticorps

N° du produit ABIN2664926

Détail du produit anti-DDX3X anticorps

Antigène: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DDX3X est non-conjugé

Application: Western Blotting (WB)

Purification: The antibody was purified by affinity chromatography.

Clone: 15D1B11

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur DDX3X

Antigène: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Autre désignation: DDX3X (DDX3X Produits)

Synonymes: anticorps DBX, anticorps DDX14, anticorps DDX3, anticorps HLP2, anticorps D1Pas1-rs2, anticorps Ddx3, anticorps Fin14, anticorps An3, anticorps pl10, anticorps DDX3X, anticorps DEAD-box helicase 3, X-linked, anticorps DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked, anticorps DEAD-box helicase 3, X-linked L homeolog, anticorps DDX3X, anticorps Ddx3x, anticorps ddx3x.L, anticorps ddx3x

Sujet: DDX3X belongs to the DEAD (Asp-Glu-Ala-Asp)-box protein family of RNA helicases, involved in the alteration of RNA secondary structure required for transcription, mRNA processing, and translation initiation. DDX3X is an essential host factor during virus infection. DDX3X serves as the cellular target of Hepatitis C virus (HCV) core protein, and also facilitates nuclear export of immature HIV RNA. The RNA helicase activity of DDX3X is required for the replication of both HCV and HIV. DDX3X is implied to act as a viral RNA sensor, mediating antiviral innate immune signaling. DDX3 participates in IκB kinase ε (IKKε) and TANK-binding kinase 1 (TBK1) dependent IRF3 activation, leading to the production of Type I interferon. DDX3X was also proposed to have antiapoptotic functions and participate in tumorigenesis.

Pathways: Ribonucleoprotein Complex Subunit Organization, Positive Regulation of Endopeptidase Activity, Negative Regulation of intrinsic apoptotic Signaling, Ribosome Assembly