ISM1 anticorps

N° du produit ABIN2665209

Détail du produit anti-ISM1 anticorps

Antigène: ISM1 (Isthmin 1 (ISM1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp ISM1 est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: B054B6

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur ISM1

Antigène: ISM1 (Isthmin 1 (ISM1))

Autre désignation: Isthmin-1 (ISM1 Produits)

Synonymes: anticorps 5430433G21Rik, anticorps Ism, anticorps C20orf82, anticorps ISM, anticorps Isthmin, anticorps bA149I18.1, anticorps dJ1077I2.1, anticorps ism, anticorps xIsm, anticorps isthmin 1, anticorps isthmin 1, angiogenesis inhibitor, anticorps isthmin 1, angiogenesis inhibitor L homeolog, anticorps ism1, anticorps Ism1, anticorps ISM1, anticorps ism1.L

Sujet: Isthmin is a secreted protein, and it was initially identified in the Xenopus midbrain-hindbrain organizer (MHB) or isthmus organizer, where it is highly expressed. The MHB is an important signaling center in vertebrates and regulates the polarized morphological differentiation of the adjacent tectum and cerebellum. Mouse Isthmin is a 454 amino acid protein containing a Thrombospondin Type 1 Repeat (TSR) domain in the central region and an Adhesion-associated domain in MUC4 and Other Proteins (AMOP) domain at the C-terminal. The TSR domains are highly conserved with 98 % identity between mouse and human, 87-88 % identity between mouse and Xenopus. The C-terminal AMOP domains are also highly conserved with 99 % identity between mouse and human, 91 % identity between mouse and Xenopus. Mouse isthmin nucleotide sequence is similar to the human chromosome 20 open reading frame 82 (C20orf82). The Ism1 gene is conserved in human, chimpanzee, dog, cow, chicken, and zebrafish. Isthmin has angiostatic activity in vitro and in vivo. Isthmin inhibits EC capillary network formation mainly by interfering with the early stages of in vitro angiogenesis on matrigel. Isthmin inhibits VEGF-induced EC proliferation and induces apoptosis in the presence of VEGF. Overexpression of isthmin in B16 melanoma inhibits tumor growth and tumor angiogenesis in mice. Knockdown of isthmin in zebrafish embryos leads to abnormal intersegmental vessel (ISV) formation in the trunk.