LAMP5 anticorps

N° du produit ABIN2665219

Détail du produit anti-LAMP5 anticorps

Antigène: LAMP5 (Lysosomal-Associated Membrane Protein Family, Member 5 (LAMP5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LAMP5 est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 124-40B

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur LAMP5

Antigène: LAMP5 (Lysosomal-Associated Membrane Protein Family, Member 5 (LAMP5))

Autre désignation: LAMP5 (LAMP5 Produits)

Synonymes: anticorps BAD-LAMP, anticorps BADLAMP, anticorps C20orf103, anticorps LAMP-5, anticorps UNC-43, anticorps 3110035N03Rik, anticorps 6330527O06Rik, anticorps C13H20orf103, anticorps lamp5, anticorps lysosomal associated membrane protein family member 5, anticorps lysosomal-associated membrane protein family, member 5, anticorps zgc:165600, anticorps LAMP5, anticorps Lamp5, anticorps zgc:165600

Sujet: Lysosome-associated membrane protein 5 (LAMP5), also known as BAD-LAMP, UNC-43, and C20orf103, is a new member of LAMP family. It is a transmembrane glycosylated protein localized in the ER-Golgi intermediate compartment (ERGIC). LAMP5 shares sequence and structural homology with the canonical LAMP1 (CD107a) and LAMP2 (CD107b) molecules, harbors an endosomal addressing signal within its cytoplasmic tail, and contains several conserved cysteine residues that allow for the formation of particular structural loops known as LAMP folds. In mice, LAMP5 is expressed in postnatal cortical neurons of particular layers, where it is enriched in defined zones along neuronal projections. Human LAMP5, like its murine homolog, is principally expressed in brain, it is also specifically found in primary CD303 (BDCA-2)-positive pDCs (plasmacytoid dendritic cells). It represents a novel marker of human primary and transformed pDCs.