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TICAM1 anticorps

TICAM1 Reactivité: Humain, Souris FACS Hôte: Souris Monoclonal 1H4B01 unconjugated
N° du produit ABIN2665411
  • Antigène Voir toutes TICAM1 Anticorps
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Reactivité
    • 25
    • 9
    • 3
    • 2
    Humain, Souris
    Hôte
    • 23
    • 3
    • 3
    Souris
    Clonalité
    • 26
    • 3
    Monoclonal
    Conjugué
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TICAM1 est non-conjugé
    Application
    • 21
    • 7
    • 7
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    1H4B01
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product TICAM1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Antigène
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Autre désignation
    TICAM-1 (TICAM1 Produits)
    Synonymes
    anticorps IIAE6, anticorps MyD88-3, anticorps PRVTIRB, anticorps TICAM-1, anticorps TRIF, anticorps AW046014, anticorps AW547018, anticorps trif, anticorps toll like receptor adaptor molecule 1, anticorps toll-like receptor adaptor molecule 1, anticorps TICAM1, anticorps Ticam1, anticorps ticam1
    Sujet
    TICAM-1, also known as TRIF, is an intracellular adaptor protein utilized by TLR3 and TLR4. TLR3 recognizes double stranded viral RNA and induces TICAM-1 mediated type I interferon production. The N-terminal region of TICAM-1 recruits TBK1 and IKKi, which in turn phosphorylates the interferon regulatory transcription factor IRF3. The phosphorylated IRF3 is subsequently dimerized and translocates to the nucleus, resulting in transcriptional activation of the gene encoding IFN-β. Mice lacking in TICAM-1 expression are defective in the TLR3 mediated induction of proinflamatory cytokines, suggesting that TICAM-1 is crucial for TLR3 downstream signaling. TICAM-1 also mediates TLR4-induced signaling in the presence of the adaptor molecule TRAM. The C-terminal region of TICAM-1 recruits RIP1 and induces apoptosis through FADD/caspase cascade.
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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