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TNF alpha anticorps
TNF alpha
Reactivité: Souris, Rat
FACS, ICFC
Hôte: Hamster
Monoclonal
TN3-19-12
unconjugated
N° du produit ABIN2665424
Détail du produit anti-TNF alpha anticorps
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Antigène
Voir toutes TNF alpha Anticorps
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Reactivité
Toutes les réactivités sur TNF alpha Anticorps
Souris, Rat
Hôte
Toutes les hôtes sur TNF alpha Anticorps
Hamster
Clonalité
Toutes les clonalités sur TNF alpha Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers TNF alpha Anticorps
Cet anticorp TNF alpha est non-conjugé
Application
Tous les applications à travers TNF alpha Anticorps.
Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
Réactivité croisée
Lapin
Purification
The antibody was purified by affinity chromatography.
Clone
TN3-19-12
Isotype
IgG
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Alternatives
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
The antibody solution should be stored undiluted between 2°C and 8°C.
Détails sur TNF alpha
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Antigène
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Autre désignation
TNF-alpha (TNF alpha Produits )
Synonymes
anticorps DIF, anticorps TNF-alpha, anticorps TNFA, anticorps TNFSF2, anticorps RATTNF, anticorps Tnfa, anticorps tnf, anticorps TNF-a, anticorps TNFalpha, anticorps Tnfsf1a, anticorps TNFa, anticorps cTNF, anticorps Tnf-alpha, anticorps tnfa-like, anticorps TNF-ALPHA, anticorps dif, anticorps tnfa, anticorps xtnf, anticorps tnfsf2, anticorps tnf-alpha, anticorps Cachectin, anticorps tumor necrosis factor, anticorps tumor necrosis factor b (TNF superfamily, member 2), anticorps tumor necrosis factor alpha, anticorps tumor necrosis factor a (TNF superfamily, member 2), anticorps TNF, anticorps Tnf, anticorps tnf, anticorps tnfb, anticorps tnf-alpha, anticorps LOC103694380, anticorps tnfa
Sujet
TNF-α is secreted by macrophages, monocytes, neutrophils, T-cells (principally CD4+), and NK-cells. Many transformed cell lines also secrete TNF-α. Monomeric mouse TNF-α is 156 amino acid protein (N-glycosylated) with a reported molecular weight of 17.5 kD protein. TNF-α forms multimeric complexes, stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. The TN3-19.12 antibody reacts with mouse, rat, and rabbit tumor-necrosis factor-α (TNF-α) proteins. The TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-α.
Pathways
Signalisation NF-kappaB , Apoptose , Caspase Cascade in Apoptosis , Signalisation TLR , Cellular Response to Molecule of Bacterial Origin , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Positive Regulation of Endopeptidase Activity , Hepatitis C , Protein targeting to Nucleus , Inflammasome
Vus récemment
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