IRF9 anticorps
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- Antigène Voir toutes IRF9 Anticorps
- IRF9 (Interferon Regulatory Factor 9 (IRF9))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp IRF9 est non-conjugé
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Application
- Flow Cytometry (FACS)
- Purification
- Affinity purified.
- Clone
- 5A3A39
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product IRF9 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Upon receipt, store undiluted 2°C and 8°C.
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- Antigène
- IRF9 (Interferon Regulatory Factor 9 (IRF9))
- Autre désignation
- IRF9 (IRF9 Produits)
- Synonymes
- anticorps IRF-9, anticorps ISGF3, anticorps ISGF3G, anticorps p48, anticorps zgc:92097, anticorps Irf-9, anticorps Isgf3g, anticorps interferon regulatory factor 9, anticorps IRF9, anticorps irf9, anticorps Irf9
- Sujet
- IRF9 is a member of the IRF family of transcription factors and plays an important role in IFN signaling pathways and anti-viral immune responses. Type I and type III interferon stimulation induces phosphorylation and heterodimerization of STAT1 and STAT2. The activated STAT1:STAT2 heterodimer recruits IRF9 and forms a heterotrimeric complex termed IFN-stimulated gene factor 3 (ISGF3). The ISGF3 complex, in turn, translocates to the nucleus and transactivates IFN-inducible genes. The IRF9 protein in the ISGF3 complex is responsible for the recognition of IFN-stimulated response elements (ISRE). Mice lacking IRF9 fail to induce the expression of IFN regulated genes in response to type I interferon stimulation, indicating that IRF9 is crucial in mediating interferon signaling.
- Pathways
- Signalistation JAK/STAT, Interferon-gamma Pathway, Hepatitis C
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