NLRP2 anticorps

N° du produit ABIN2666255

Détail du produit anti-NLRP2 anticorps

Antigène: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NLRP2 est non-conjugé

Application: Functional Studies (Func), Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 8F10B51

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Upon receipt, store undiluted at 4°C

Détails sur NLRP2

Antigène: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Autre désignation: NLRP2 (NLRP2 Produits)

Synonymes: anticorps CLR19.9, anticorps NALP2, anticorps NBS1, anticorps PAN1, anticorps PYPAF2, anticorps NLRP2, anticorps E330007A02Rik, anticorps Nalp2, anticorps NLR family pyrin domain containing 2, anticorps NACHT, LRR and PYD domains-containing protein 2, anticorps NLR family pyrin domain containing 7, anticorps NLR family, pyrin domain containing 2, anticorps NLRP2, anticorps LOC100301026, anticorps LOC100387349, anticorps NLRP7, anticorps Nlrp2

Sujet: NLRP2, also known as NALP2 or PAN1, is a member of the pyrin domain-containing NLR protein (NLRP) family. The NLR proteins interact with ASC via the conserved pyrin domain, which results in the activation of caspase-1 and maturation of the pro-inflammatory cytokines IL-1β and IL-18. NLRP2 is also involved in the formation of the inflammasome and caspase-1 activation. NLRP2 negatively regulates NFκB activation, which is induced by TNF-α, through inhibiting NFKBIA degradation. In addition, NLRP2 is one of the maternal effect genes and plays a crucial role in embryonic development. In mouse embryos, knockdown or mutation of NLRP2 leads to developmental defections. Truncation of the NLRP2 gene is reported to associate with an overgrowth discorder called Beckwith-Wiedemann Syndrome.

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome