EZH2 anticorps (AA 1-370)

N° du produit ABIN2668958

Détail du produit anti-EZH2 anticorps

Antigène: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Épitope: AA 1-370

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EZH2 est non-conjugé

Application: Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Purification: None

Immunogène: This EZH2 antibody was raised against a recombinant fusion protein corresponding to amino acids 1-370 of mouse EZH2.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Stock: -20 °C

Stockage commentaire: Antibodies in solution can be stored at -20 °C for 2 years.

Date de péremption: 6 months

Références pour anticorps anti-EZH2 (ABIN2668958)

LaFave, Béguelin, Koche, Teater, Spitzer, Chramiec, Papalexi, Keller, Hricik, Konstantinoff, Micol, Durham, Knutson, Campbell, Blum, Shi, Doud, Krivtsov, Chung, Khodos, de Stanchina, Ouerfelli et al.: "Loss of BAP1 function leads to EZH2-dependent transformation. ..." dans: Nature medicine, Vol. 21, Issue 11, pp. 1344-9, (2015) (PubMed).

Knutson, Kawano, Minoshima, Warholic, Huang, Xiao, Kadowaki, Uesugi, Kuznetsov, Kumar, Wigle, Klaus, Allain, Raimondi, Waters, Smith, Porter-Scott, Chesworth, Moyer, Copeland, Richon, Uenaka, Pollock et al.: "Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. ..." dans: Molecular cancer therapeutics, Vol. 13, Issue 4, pp. 842-54, (2014) (PubMed).

Inoue, Kitaura, Togami, Nishimura, Enomoto, Uchida, Kagiyama, Kawabata, Nakahara, Izawa, Oki, Maehara, Isobe, Tsuchiya, Harada, Harada, Ochiya, Aburatani, Kimura, Thol, Heuser, Levine, Abdel-Wahab et al.: "Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations. ..." dans: The Journal of clinical investigation, Vol. 123, Issue 11, pp. 4627-40, (2014) (PubMed).

Kumar, Duester: "Retinoic acid controls body axis extension by directly repressing Fgf8 transcription." dans: Development (Cambridge, England), Vol. 141, Issue 15, pp. 2972-7, (2014) (PubMed).

Tong, He, Xie, Mochizuki, Liu, Mochizuki, Meng, Sun, Zhang, Guo, Hexner, Zhang: "Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 5012-22, (2014) (PubMed).

Bender, Tang, Lindroth, Hovestadt, Jones, Kool, Zapatka, Northcott, Sturm, Wang, Radlwimmer, Højfeldt, Truffaux, Castel, Schubert, Ryzhova, Seker-Cin, Gronych, Johann, Stark, Meyer, Milde, Schuhmann et al.: "Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. ..." dans: Cancer cell, Vol. 24, Issue 5, pp. 660-72, (2013) (PubMed).

Chng, Chang, Tan, Yang, Hong, Sng, Cheung: "A transcriptional repressor co-regulatory network governing androgen response in prostate cancers." dans: The EMBO journal, Vol. 31, Issue 12, pp. 2810-23, (2012) (PubMed).

Abdel-Wahab, Adli, LaFave, Gao, Hricik, Shih, Pandey, Patel, Chung, Koche, Perna, Zhao, Taylor, Park, Carroll, Melnick, Nimer, Jaffe, Aifantis, Bernstein, Levine: "ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression." dans: Cancer cell, Vol. 22, Issue 2, pp. 180-93, (2012) (PubMed).

Bredfeldt, Greathouse, Safe, Hung, Bedford, Walker: "Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT." dans: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 5, pp. 993-1006, (2010) (PubMed).

Détails sur EZH2

Antigène: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Autre désignation: EZH2 (EZH2 Produits)

Poids moléculaire: 96 kDa

ID gène: 2146

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation