5-Hydroxymethylcytosine anticorps
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- Antigène Tous les produits 5-Hydroxymethylcytosine (5-hmC)
- 5-Hydroxymethylcytosine (5-hmC)
- Reactivité
- Veuillez nous consulter SVP
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp 5-Hydroxymethylcytosine est non-conjugé
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Application
- Dot Blot (DB), Methylated DNA Immunoprecipitation (MeDIP)
- Purification
- Protein A Chromatography
- Immunogène
- This 5-Hydroxymethylcytidine antibody was raised against 5-hydroxymethylcytidine conjugated to KLH and recognizes 5-hydroxymethylcytosine.
- Isotype
- IgG
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1 μg/μL
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
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Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- Stock
- -20 °C
- Stockage commentaire
- Antibodies in solution can be stored at -20 °C for 2 years.
- Date de péremption
- 6 months
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Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation." dans: Molecular and cellular biology, Vol. 36, Issue 3, pp. 452-61, (2016) (PubMed).
: "5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma." dans: Clinical epigenetics, Vol. 8, pp. 31, (2016) (PubMed).
: "5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer." dans: Genome biology, Vol. 16, pp. 69, (2015) (PubMed).
: "Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency. ..." dans: Nature communications, Vol. 6, pp. 7095, (2015) (PubMed).
: "5-Carboxylcytosine levels are elevated in human breast cancers and gliomas." dans: Clinical epigenetics, Vol. 7, pp. 88, (2015) (PubMed).
: "Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism." dans: Nucleic acids research, Vol. 42, Issue 3, pp. 1593-605, (2014) (PubMed).
: "TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation." dans: Nucleic acids research, Vol. 42, Issue 13, pp. 8592-604, (2014) (PubMed).
: "Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA." dans: Nature, Vol. 506, Issue 7488, pp. 391-5, (2014) (PubMed).
: "Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 36, pp. 14682-7, (2013) (PubMed).
: "Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming." dans: Cell research, Vol. 23, Issue 3, pp. 329-39, (2013) (PubMed).
: "Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics." dans: Cell, Vol. 153, Issue 3, pp. 692-706, (2013) (PubMed).
: "Naive pluripotency is associated with global DNA hypomethylation." dans: Nature structural & molecular biology, Vol. 20, Issue 3, pp. 311-6, (2013) (PubMed).
: "Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster." dans: Nature communications, Vol. 3, pp. 818, (2012) (PubMed).
: "Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells." dans: Genes & development, Vol. 25, Issue 7, pp. 679-84, (2011) (PubMed).
: "Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies." dans: Blood, Vol. 118, Issue 17, pp. 4509-18, (2011) (PubMed).
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Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation." dans: Molecular and cellular biology, Vol. 36, Issue 3, pp. 452-61, (2016) (PubMed).
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- Antigène
- 5-Hydroxymethylcytosine (5-hmC)
- Autre désignation
- 5-Hydroxymethylcytosine (5-hmC Produits)
- Classe de substances
- Chemical
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