This antibody reacts with the 65-70 kDa common γ subunit (γc) shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors. The γc receptor is a glycoprotein expressed by most peripheral T and B lymphocytes, NK cells, monocytes, and granulocytes. The cytoplasmic domain of the γc chain plays an important role in cytokine-mediated signal transduction. By immunofluorescent staining and flow cytometric analysis, the TUGh4 antibody has been shown to specifically recognize human γc expressed by cell lines, including human γc gene-transfected cell lines, which are known to express the human γc chain.
BD Pharmingen™ Purified Rat Anti-Human CD132 - Purified - Clone TUGh4 - Isotype Rat IgG2b, κ - Reactivity Hu, Dog - 0.5 mg
Purification
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store undiluted at 4°C.
Ishii, Takeshita, Kimura, Tada, Kondo, Nakamura, Sugamura: "Expression of the IL-2 receptor gamma chain on various populations in human peripheral blood." dans: International immunology, Vol. 6, Issue 8, pp. 1273-7, (1995) (PubMed).