Reacts with IL-12Rβ1 subunit, one of two subunits of the IL-12Rβ. IL-12R, expressed mainly on T cells or NK cells, is a member of the hemopoietin receptor superfamily and is related to gp130, granulocyte-colony stimulating factor (G-CSF) receptor and leukemia inhibitory factor (LIF). Reports indicate that together, subunits IL-12Rβ1 and IL-12Rβ2 bind IL-12 with high affinity. IL-12 is an immunomodulatory cytokine produced mainly by antigen-presenting cells (APC) and plays a role in promoting Th1-type responses and cell-mediated immunity. It stimulates proliferation of T cells and NK cells, enhances lytic activity of lymphokine-activated killer (LAK) cells and CTL. Profile of IL-12Rβ1 expressed on peripheral blood lymphocytes analyzed on a FACScan .
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Presky, Minetti, Gillessen, Wilkinson, Wu, Gubler, Chizzonite, Gately: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, (1998) (PubMed).
Wu, Warrier, Carvajal, Chua, Minetti, Chizzonite, Mongini, Stern, Gubler, Presky, Gately: "Biological function and distribution of human interleukin-12 receptor beta chain." dans: European journal of immunology, Vol. 26, Issue 2, pp. 345-50, (1996) (PubMed).