The M.Ab.F11 monoclonal antibody specifically binds to CD321 which is also known as JAM-1 (Junctional adhesion molecule 1), Junctional adhesion molecule A (JAM-A), and F11 Receptor (F11R). CD321 is a 32-35 kDa type I transmembrane glycoprotein that includes two extracellular immunoglobulin-like domains. CD321 is expressed on platelets, leucocytes, red blood cells, endothelial cells, epithelial cells, and various cell lines. CD321 functions as an adhesion receptor molecule on platelets. It also supports the tight junction formation between endothelial cells, where it may regulate the transendothelial migration of leucocytes, and epithelial cells. M.Ab.F11 is a stimulatory antibody that can induce morphological changes, granule secretion, and aggregation in human platelets. Flow cytometric analysis of human CD321 staining on platelets. Peripheral blood platelets were stained with either Purified Mouse Anti-Human CD321 (JAM-1) (Cat. No. 552147, solid line histogram) or Purified Mouse IgG1, κ Isotype Control (Cat. No. 555746, dashed line histogram), followed by second step staining with FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988).
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