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CD77 anticorps

Reactivité: Humain FACS Hôte: Souris Monoclonal 5B5 unconjugated
N° du produit ABIN2689395
  • Antigène Tous les produits CD77
    CD77
    Reactivité
    Humain
    Hôte
    • 6
    • 1
    Souris
    Clonalité
    • 7
    Monoclonal
    Conjugué
    • 3
    • 2
    • 2
    Cet anticorp CD77 est non-conjugé
    Application
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Marque
    BD Pharmingen™
    Attributs du produit
    Reacts with CD77, a small neutral glycosphingolipid, 1 kDa, also referred to as globotriaosylceramide (Gb3). CD77 is expressed on a subset of germinal center B-lymphocytes and not on peripheral blood lymphocytes, bone marrow or spleen. It has been described as a receptor for Shiga Toxin, produced by Shigella dysenteriae, and Verotoxin 1 (VT1), produced by some strains of E. coli. CD19 has been reported as a ligand for CD77 and these interaction functions in adhesion and signal transduction at a specific stage of B cell development. Studies have shown that cross-linking CD77 induces apoptosis in some B cell lines. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of Ramos cell line analyzed by flow cytometry. Second step staining with Cat. No. 555988.

    BD Pharmingen™ Purified Mouse Anti-Human CD77 - Purified - Clone 5B5 - Isotype Mouse IgM, κ - Reactivity Hu - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Clone
    5B5
    Isotype
    IgM kappa
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Lagresle, Bella, Daniel, Krammer, Defrance: "Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 11, pp. 5746-56, (1995) (PubMed).

    Mangeney, Rousselet, Taga, Tursz, Wiels: "The fate of human CD77+ germinal center B lymphocytes after rescue from apoptosis." dans: Molecular immunology, Vol. 32, Issue 5, pp. 333-9, (1995) (PubMed).

    Fyfe, Cebra-Thomas, Mustain, Davie, Alley, Nahm: "Subpopulations of B lymphocytes in germinal centers." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 7, pp. 2187-94, (1987) (PubMed).

  • Antigène
    CD77
    Abstract
    CD77 Produits
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