alpha Adducin anticorps

N° du produit ABIN271922

Détail du produit anti-alpha Adducin anticorps

Antigène: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha Adducin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of ADD1 protein. (regioin surrounding Lys439)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur alpha Adducin

Antigène: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Autre désignation: alpha-Adducin (ADD1) (ADD1 Produits)

Synonymes: anticorps ADDA, anticorps AI256389, anticorps alpha-adducin, anticorps bZ1H20.1, anticorps cb787, anticorps zgc:158352, anticorps add2, anticorps adda, anticorps add1-a, anticorps ADD1, anticorps adducin 1, anticorps adducin 1 (alpha), anticorps adducin 1 S homeolog, anticorps ADD1, anticorps Add1, anticorps add1, anticorps add1.S

Sujet: Adducins are a family of cytoskeleton proteins encoded by three genes (α, β, γ). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin α is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin α and Adducin γ is ubiquitous in contrast to the restricted expression of Adducin β. Adducin β is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.Synonyms: ADDA, Erythrocyte adducin subunit alpha

Poids moléculaire: approx. 81 kDa

ID gène: 118

NCBI Accession: NP_001110

UniProt: P35611

Pathways: Negative Regulation of Hormone Secretion, Regulation of Actin Filament Polymerization, Regulation of Lipid Metabolism by PPARalpha, ER-Nucleus Signaling