PBK anticorps
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- Antigène Voir toutes PBK Anticorps
- PBK (PDZ Binding Kinase (PBK))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PBK est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects endogenous levels of PBK/TOPK protein. (region surrounding Ile4)
- Réactivité croisée (Details)
- Species reactivity (tested):Human.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- Pureté
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product PBK Anticorps primaire
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- Indications d'application
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ELISA: 1: 21000approx. 1: 5000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should bedetermined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- DO NOT FREEZE!
- Stock
- 4 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C.
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- Antigène
- PBK (PDZ Binding Kinase (PBK))
- Autre désignation
- PBK / TOPK (PBK Produits)
- Synonymes
- anticorps PBK, anticorps topk, anticorps CT84, anticorps Nori-3, anticorps SPK, anticorps TOPK, anticorps 2810434B10Rik, anticorps AW538537, anticorps D14Ertd732e, anticorps zgc:92050, anticorps PDZ binding kinase, anticorps PDZ binding kinase L homeolog, anticorps PBK, anticorps pbk, anticorps Pbk, anticorps pbk.L
- Sujet
- PBK (PDZ binding kinase) belongs to the serine/threonine protein kinase family. It is related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family and phosphorylates MAP kinase p38. It is active only in mitosis. When phosphorylated it forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. It makes a kinase-substrate complex with cdk1/cyclin B1 and PRC1 on microtubules during mitosis, enhances the cdk1/cyclin B1-dependent phosphorylation of PRC1 and thereby strongly promotes cytokinesis. It may play a role in the activation of lymphoid cells.Synonyms: CT84, Cancer/testis antigen 84, Lymphokine-activated killer T-cell-originated protein kinase, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, SPK, T-LAK cell-originated protein kinase
- Poids moléculaire
- approx. 36 kDa
- ID gène
- 55872
- NCBI Accession
- NP_060962
- UniProt
- Q96KB5
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