HMGB1 anticorps

N° du produit ABIN272158

Détail du produit anti-HMGB1 anticorps

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGB1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of HMG-1 protein. (region surrounding Ala164)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/20000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HMGB1

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Autre désignation: HMGB1 (HMGB1 Produits)

Synonymes: anticorps HMG1, anticorps HMG3, anticorps SBP-1, anticorps DEF, anticorps HMG-1, anticorps Hmg1, anticorps amphoterin, anticorps p30, anticorps hmgb1, anticorps ik:tdsubc_1a5, anticorps wu:fb23c02, anticorps xx:tdsubc_1a5, anticorps zgc:56110, anticorps zgc:77104, anticorps hmg-1, anticorps hmg3, anticorps sbp-1, anticorps hmg1, anticorps HMGB1, anticorps Ac2-008, anticorps high mobility group box 1, anticorps high-mobility group box 1, anticorps high mobility group box 1a, anticorps high mobility group box 1 L homeolog, anticorps high mobility group protein B1, anticorps HMGB1, anticorps Hmgb1, anticorps hmgb1, anticorps hmgb1a, anticorps hmgb1.L, anticorps LOC100359149

Sujet: High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Research suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture, including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, ATF-2, c-Jun and members of the NFκB family to activate transcription. Additional studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 each contain two DNA-binding domains, termed HMG boxes. HMG proteins bind singlestranded DNA but induce conformational changes in double-stranded DNA alone.Synonyms: Amphoterin, HMG-1, HMG1, HMGB-1, High mobility group protein 1, High mobility group protein B1

Poids moléculaire: approx. 25 kDa

ID gène: 3146

NCBI Accession: NP_002119

UniProt: P09429

Pathways: Signalisation p53, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome