NCBP2
Reactivité: Humain, Souris, Rat
WB, IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps CBP20, anticorps CG12357, anticorps Dmel\\CG12357, anticorps 20kDa, anticorps 5930413E18Rik, anticorps AA536802, anticorps AI843301, anticorps C79367, anticorps CHUNP6917, anticorps zgc:92592, anticorps CBC2, anticorps NIP1, anticorps ATCBP20, anticorps CAP-binding protein 20, anticorps MLN1.12, anticorps MLN1_12, anticorps Ncbp2, anticorps cap binding protein 20, anticorps nuclear cap binding protein subunit 2, anticorps nuclear cap binding protein subunit 2, 20kDa, anticorps nuclear cap binding protein subunit 2 L homeolog, anticorps nuclear cap-binding protein subunit 2, anticorps CAP-binding protein 20, anticorps Nuclear cap-binding protein subunit 2, anticorps Cbp20, anticorps Ncbp2, anticorps ncbp2, anticorps NCBP2, anticorps ncbp2.L, anticorps CBP20, anticorps ncbp-2
Sujet
In eukaryotes, the majority of mRNAs have an m(7)G cap, which is added cotranscriptionally and plays a critical role in many aspects of mRNA metabolism. The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC). CBC consists of two cap binding proteins, CBP20 and CBP80, which mediate the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation and U snRNA export. The genes CBC1 and CBC2 encode CBP80 and CBP20, respectively. CBP80 comprises three domains, each containing a MIF4G domain. CBP20 has an RNAP fold and associates with the second and third domains of CBP80. CBP also plays a role in nonsense-mediated decay (NMD), a process which eliminates mRNAs, and prematurely terminates translation. CBP80-bound mRNA undergoes a pioneer round of translation before CBP80-CBP20 are replaced by eIF4E, and Upf2 and Upf3 proteins.Synonyms: CBP20, Nuclear cap-binding protein subunit 2, PIG55