Keratin 6 anticorps (C-Term)

N° du produit ABIN2742495

Détail du produit anti-Keratin 6 anticorps

Antigène: Keratin 6 (KRT6)

Épitope: C-Term

Reactivité: Humain, Chimpanzé, Gibbon, Cheval, Orang-Utan

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Keratin 6 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: Human KRT6 / CK6 / Cytokeratin 6

Purification: Protein G purified

Immunogène: A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from the C-terminus of human Cytokeratin 6. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Horse (100%), Marmoset, Mouse, Rat, Ferret, Bat, Hamster, Elephant, Dog (91%), Sheep, Bovine (82%).

Type of Immunogen: Synthetic peptide

Clone: LHK6

Isotype: IgG2a kappa

Information d'application

Indications d'application: Approved: Flo (0.5 - 1 μg/10 x10⁶), IF (0.5 - 1 μg/mL), IHC, IHC-P (0.5 - 1 μg/mL)

Usage: This antibody recognizes a protein of 56  kDa, identified as cytokeratin 6 (CK6) or Keratin 6. In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express Cytokeratin 6 and 16. Keratin 6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of Cytokeratin 6 is particularly associated with differentiation. ELISA: Order BSA-free antibody format for coating.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2°C to 8°C.

Détails sur Keratin 6

Antigène: Keratin 6 (KRT6)

Autre désignation: KRT6 / CK6 / Cytokeratin 6 (KRT6 Produits)

Synonymes: anticorps Krt2-6, anticorps Krt-2.6, anticorps keratin 6, anticorps Krt6